Sumesh Sasidharan

My research

MYOCAR3 - Development of a D3(Data Driven Diagnostic) and Therapeutic approach for Acute Myocarditis among Young Adults

Myocarditis develops when the heart muscle becomes inflamed and enlarged, thus weakening the heart. Clinically it has been frequently under-recognized and often ignored, but the associated risk of sudden cardiac death (SCD) for people especially in young adults is a reason for concern. In fact, it most often affects people who are healthy and athletic with the high-risk population being those of ages from puberty through their early 30’s, affecting males twice as often as females.The aim of the proposed research is to develop a therapeutic management approach for acute myocarditis by using clinical imaging data and patient specific models of myocardium. It will integrate multiscale poroelastic model with an immune response model and thereby characterise haemodynamic changes in response to the acute inflammation of the myocardium in young adults. On that level, this multi-stage and multiscale project will integrate magnetic resonance imaging with finite element (FE) modelling of myocardial contraction, deformation and perfusion. The interdisciplinary and intersectoral perspective in this study is strong with contributions from engineers, mathematicians and with secondment at cardiovascular imaging divison of CIVIS partnering hospital. The scope of the study is usage of FE modelling for autoregulation of cardiac perfusion which extends the applications of FE model to common pathologies such as ischemic heart disease, infarction or reperfusion issues and devices such as stents or cardiac assist devices, that improve cardiac blood perfusion. This project is in line with the CIVIS themes to promote research in the field of health and allied areas.

Date started – Date End

15.03.2024 au 14.03.2026